LC-MS/MS analysis couples liquid chromatography with tandem mass spectrometry to identify and quantify non-volatile and thermolabile compounds, including pesticide residues, mycotoxins and veterinary drug residues, at the low detection limits required by EU food safety rules.
In trade practice
Laboratories choose LC-MS/MS over GC-MS when target analytes would degrade under the high temperatures of gas chromatography. In agri-food trade, it is routinely applied to aflatoxins, ochratoxin A, certain pesticides and veterinary drug residues in honey and animal-derived products. Buyers should confirm that the laboratory’s accredited scope under ISO 17025 covers the specific analyte groups required for their product category. Results appear on the certificate of analysis alongside the method reference and the limit of quantification.
In a specification
A specification or testing protocol names LC-MS/MS as the required analytical technique for defined analyte groups, referencing the relevant EU maximum levels regulation and requiring ISO 17025 accreditation for the method.